Table 2.
Metabolic Outcome Measures in Each Analytic Outcome Subgroup Comparing Obese PHACS SMARTT vs. NHANES Participants
| Metabolic Outcome | Cohort | p-value | |
|---|---|---|---|
| SMARTT HEU | NHANES | ||
| Blood Pressure | n=304 | n=792 | |
| Systolic BP Z-score | 0.75 (0.12, 1.34) | 0.11 (−0.43, 0.68) | <0.01 |
| Abnormal Systolic BP (≥90th percentile) | 84 (28%) | 70 (9%) | <0.01 |
| Diastolic BP Z-score | 0.26 (−0.18, 0.74) | −0.44 (−1.13, 0.26) | <0.01 |
| Abnormal Diastolic BP (≥90th percentile) | 21 (7%) | 27 (3%) | 0.02 |
| Abnormal Systolic or Diastolic BP (Systolic or Diastolic BP >90th percentile) | 92 (30%) | 89 (11%) | <0.01 |
| TC and HDL | n=385 | n=916 | |
| TC (mg/dL) | 155 (138, 178) | 162 (145, 182) | <0.01 |
| Hypercholesterolemia (> 200 mg/dL) | 31 (8%) | 104 (11%) | 0.09 |
| HDL (mg/dL) | 47 (40, 55) | 46 (40, 53) | 0.18 |
| Low HDL (< 35 mg/dL) | 32 (8%) | 72 (8%) | 0.82 |
| TG, LDL, and HOMA-IR | n=83 | n=188 | |
| TG (mg/dL) | 66 (54, 100) | 77 (55, 117) | 0.22 |
| Hypertriglyceridemia (> 150 mg/dL) | 8 (10%) | 23 (12%) | 0.68 |
| LDL (mg/dL) | 88 (73, 104) | 94 (73, 110) | 0.43 |
| High LDL (> 130 mg/dL) | 8 (10%) | 18 (10%) | 1.00 |
| HOMA-IR | 4.05 (2.50, 5.93) | 5.47 (3.96, 7.51) | <0.01 |
| Insulin Resistant (> 4.0) | 42 (51%) | 140 (74%) | <0.01 |
| Systolic BP Z-score | 0.75(0.12, 1.34) | 0.11 (−0.43,0.68) | <0.01 |
| Abnormal Systolic BP (≥ 90th percentile) | 84 (28%) | 70 (9%) | <0.01 |
| Diastolic BP Z-score | 0.26 (−0.18, 0.74) | −0.44 (−1.13, 0.26) | <0.01 |
| Abnormal Diastolic BP (≥ 90th percentile) | 21 (7%) | 27 (3%) | 0.02 |
| Abnormal Systolic or Diastolic BP (Systolic or Diastolic BP ≥ 90th percentile) | 92 (30%) | 89(11%) | <0.01 |
| TC and HDL | n=385 | n=916 | |
All continuous variables expressed as median (interquartile range) and categorical variables as n (%). BP=Blood Pressure; HDL=High-Density Lipoprotein cholesterol; HEU=HIV-exposed uninfected; HOMA-IR=Homeostatic Model of Assessment-Insulin Resistance; LDL=Low-Density Lipoprotein cholesterol; PHACS=Pediatric HIV/AIDS Cohort Study; NHANES=National Health and Nutrition Examination Survey; SMARTT= Surveillance Monitoring of ART Toxicities study; TC=Total Cholesterol; TG=Triglycerides.