TABLE 1.
Univariate Analysis of Clinical, Pathological, and Biomarker Data Associated With Liver Metastases
| Variables | All Patients n = 87 | ALT n = 85 |
P | Liver Metastases n = 87 |
P | ||
|---|---|---|---|---|---|---|---|
| Negative n = 58 | Positive n = 27 | No n = 55 | Yes n = 32 | ||||
| Male, no. (%) | 44 (50.6) | 32 (55.2) | 12 (44.4) | 0.485 | 27 (49.1) | 17 (53.1) | 0.825 |
| Age, mean (SD), yr | 57 (12) | 57 (17) | 57 (19) | 0.884 | 58 (12) | 56 (13) | 0.483 |
| Location of tumor | 0.643 | 0.115 | |||||
| Head and uncinate, no. (%) | 36 (41.4) | 25 (43.1) | 10 (37.0) | 19 (34.5) | 17 (53.1) | ||
| Body and tail, no. (%) | 51 (58.6) | 33 (56.9) | 17 (63) | 15 (46.9) | 36 (65.5) | ||
| Tumor size, median (IQR), cm | 2.2 (1.1) | 2.0 (1.1) | 2.5 (0.9) | 0.070 | 2.0 (1.1) | 2.5 (0.8) | 0.010 |
| Size | 0.098 | 0.023 | |||||
| ≤ cm | 6 (6.9) | 6 (10.3) | 0 (0.0) | 6 (10.9) | 0 (0) | ||
| 1–2 cm | 36 (41.4) | 25 (43.1) | 9 (33.3) | 26 (47.3) | 10 (31.3) | ||
| >2 cm | 45 (51.7) | 27 (46.6) | 18 (66.7) | 23 (41.8) | 22 (68.8) | ||
| Ki67 index %, median (IQR) | 2.0 (3.3) | 1.2 (2.3) | 4.0 (4.3) | 0.001 | 1.0 (2.1) | 4.2 (6.7) | ≤0.001 |
| WHO grade | 0.004 | 0.001 | |||||
| G1, no. (%) | 54 (62.1) | 42 (72.4) | 10 (37.0) | 42 (76.4) | 12(37.5) | ||
| G2, no. (%) | 33 (37.9) | 16 (27.6) | 17 (63.0) | 13 (23.6) | 20 (62.5) | ||
| Lymphovascular invasion, no. (%) | 19 (21.8) | 8 (13.8) | 11 (40.7) | 0.010 | 8 (14.5) | 11 (34.4) | 0.057 |
| Perineural invasion, no. (%) | 26 (29.9) | 10 (17.2) | 15 (55.6) | 0.001 | 10 (18.2) | 16 (50) | 0.003 |
| T stage, no. (%) | 0.210 | 0.215 | |||||
| T1 stage, no. (%) | 36 (41.4) | 26 (44.8) | 10 (37.0) | 26 (47.3) | 10 (31.3) | ||
| T2 stage, no. (%) | 31 (35.6) | 17 (29.3) | 13 (48.1) | 16 (29.1) | 15 (46.9) | ||
| T3 stage, no. (%) | 20 (23.0) | 15 (25.9) | 4 (14.8) | 13 (23.6) | 7 (21.9) | ||
| N stage, no. (%) | 0.007 | ≤0.001 | |||||
| Nx-0 stage, no. (%) | 58 (66.7) | 44 (75.9) | 12 (44.4) | 45 (81.8) | 13 (40.6) | ||
| N1 stage, no. (%) | 29 (33.3) | 14 (24.1) | 15 (55.6) | 10 (18.2) | 19 (59.4) | ||
| Liver metastases, no. (%) | 32 (36.8) | 14 (24.1) | 18 (66.7) | ≤0.001 | |||
| ALT pos, no. (%) | 27/85 (31.8) | 9/53 (17) | 18/32 (56.3) | ≤0.001 | |||
| DAXX neg, no. (%) | 20/84 (23.8) | 1 (1.8) | 19 (70.4) | ≤0.001 | 7/52 (13.5) | 13/32 (40.6) | 0.008 |
| ATRX neg, no. (%) | 6/85 (7.1) | 0 (0) | 6 (22.2) | 0.001 | 3/53 (5.7) | 3/32 (9.4) | 0.668 |
P values in bold represent significant statistical differences.