. 2019 Apr 9;7(6):e677. doi: 10.1002/mgg3.677

Table 2.

Distribution of BRCA2 * mutations in 216 patients with high‐risk breast cancer

Patient ID	Nucleotide change	Exon	Amino acid change	Mutation type	Pathogenicity	BIC	ClinVar	Age at diagnosis (years)	Cancer family history	Triple‐negative breast cancer
033A	c.304A>T	3	p.Lys102Ter	Nonsense	Pathogenic	No	No	28	Father pancreatic cancer	No
192A	c.464_468delGAGAT	5	p.Arg155Lysfs*26	Missense	Unknown	No	Yes	45	No	No
073A	c.5959C>T	11	p.Gln1987Ter	Nonsense	Pathogenic	Yes	Yes	47	Father pancreatic cancer; older sister breast cancer	No
212A	c.5959C>T	11	p.Gln1987Ter	Nonsense	Pathogenic	Yes	Yes	36	No	No
064A	c.7552_7553insT	15	p.Pro2519Alafs*20	Missense	Pathogenic	No	No	33	No	No
140A	c.8364G>A	—	p.Trp2788Ter	Nonsense	Pathogenic	No	Yes	42	No	Yes
141A	c.9548_9549insA	—	p.Leu3184Thrfs*5	Missense	Pathogenic	No	No	41	Father bladder cancer	No

BIC: breast cancer information core.