Table 4.
BRCA1/2 * genotype‐phenotype correlations
| Feature | Number of patients | Patients with variants, n (%) | Patients without variants, n (%) | p |
|---|---|---|---|---|
| N | 216 | 18 (8.3) | 198 (91.7) | |
| Age at diagnosis (year) | 0.28 | |||
| ≤35 | 43 | 6 (14.0) | 37 (86.0) | |
| 35–40 | 52 | 5 (9.6) | 47 (90.4) | |
| 40–45 | 80 | 6 (7.5) | 74 (92.5) | |
| >45 | 41 | 1 (2.4) | 40 (97.6) | |
| Cancer family history | 0.52 | |||
| Yes | 47 | 5 (10.6) | 42 (89.4) | |
| No | 169 | 13 (7.7) | 156 (92.3) | |
| ≥2 primary lesions | 0.61 | |||
| Yes | 7 | 1 (14.3) | 6 (85.7) | |
| No | 209 | 17 (8.1) | 192 (91.9) | |
| Tumor size (cm) | 0.42 | |||
| In situ cancer | 6 | 0 (0.0) | 6 (100.0) | |
| ≤2 | 133 | 12 (9.0) | 121 (91.0) | |
| >2 | 70 | 4 (5.7) | 66 (94.3) | |
| Lymph node metastasis | 0.59 | |||
| Yes | 87 | 9 (10.3) | 78 (89.7) | |
| No | 121 | 8 (6.6) | 113 (93.4) |
*
BRCA1 (NM_007294.3) and BRCA2 (NM_000059.3).