Table 3.
Genetics model analysis of association between MIR17HG polymorphisms and colorectal cancer risk
| SNP‐ID | Model | Genotype | Case | Control | OR (95% CI) | p | Adjusted OR (95% CI) | Adjusted p |
|---|---|---|---|---|---|---|---|---|
| rs72640334 | Codominant | CC | 426 | 416 | 1.00 | 1.00 | ||
| CA | 75 | 90 | 0.81 (0.58–1.14) | 0.228 | 0.82 (0.58–1.14) | 0.234 | ||
| AA | 5 | 4 | 1.22 (0.33–4.58) | 0.768 | 1.23 (0.33–4.60) | 0.763 | ||
| Dominant | CC | 426 | 416 | 1.00 | 1.00 | |||
| AA + CA | 80 | 94 | 0.83 (0.60–1.15) | 0.268 | 0.83 (0.60–1.16) | 0.275 | ||
| Recessive | CC + CA | 501 | 506 | 1.00 | 1.00 | |||
| AA | 5 | 4 | 1.26 (0.34–4.73) | 0.729 | 1.27 (0.34–4.75) | 0.725 | ||
| Additive | – | – | – | 0.86 (0.64–1.17) | 0.344 | 0.87 (0.64–1.17) | 0.352 | |
| rs7336610 | Codominant | CC | 109 | 142 | 1.00 | 1.00 | ||
| TC | 240 | 230 | 1.36 (1.00–1.85) | 0.051 | 1.36 (1.00–1.85) | 0.051 | ||
| TT | 165 | 137 | 1.57 (1.12–2.20) | 0.009 | 1.57 (1.12–2.20) | 0.009 | ||
| Dominant | CC | 109 | 142 | 1.00 | 1.00 | |||
| TT + TC | 405 | 367 | 1.44 (1.08–1.92) | 0.013 | 1.44 (1.08–1.92) | 0.013 | ||
| Recessive | CC + TC | 349 | 372 | 1.00 | 1.00 | |||
| TT | 165 | 137 | 1.28 (0.98–1.68) | 0.069 | 1.28 (0.98–1.68) | 0.070 | ||
| Additive | – | – | – | 1.25 (1.06–1.48) | 0.010 | 1.25 (1.06–1.48) | 0.010 | |
| rs7318578 | Codominant | AA | 277 | 245 | 1.00 | 1.00 | ||
| CA | 199 | 227 | 0.78 (0.60–1.00) | 0.052 | 0.78 (0.60–100) | 0.054 | ||
| CC | 35 | 38 | 0.81 (0.50–1.33) | 0.413 | 0.82 (0.50–1.33) | 0.417 | ||
| Dominant | AA | 277 | 245 | 1.00 | 1.00 | |||
| CC + CA | 234 | 265 | 0.78 (0.61–1.00) | 0.049 | 0.78 (0.61–1.00) | 0.051 | ||
| Recessive | AA + CA | 476 | 472 | 1.00 | 1.00 | |||
| CC | 35 | 38 | 0.91 (0.57–1.47) | 0.709 | 0.91 (0.57–1.47) | 0.713 | ||
| Additive | – | – | – | 0.84 (0.69–1.02) | 0.083 | 0.84 (0.69–1.03) | 0.087 | |
| rs17735387 | Codominant | GG | 361 | 335 | 1.00 | 1.00 | ||
| GA | 137 | 158 | 0.80 (0.61–1.06) | 0.119 | 0.80 (0.61–1.06) | 0.116 | ||
| AA | 16 | 17 | 0.87 (0.43–1.76) | 0.704 | 0.87 (0.43–1.75) | 0.695 | ||
| Dominant | GG | 361 | 335 | 1.00 | 1.00 | |||
| AA + GA | 153 | 175 | 0.81 (0.62–1.06) | 0.119 | 0.81 (0.62–1.05) | 0.116 | ||
| Recessive | GG + GA | 498 | 493 | 1.00 | 1.00 | |||
| AA | 16 | 17 | 0.93 (0.47–1.87) | 0.842 | 0.93 (0.46–1.87) | 0.837 | ||
| Additive | – | – | – | 0.85 (0.68–1.07) | 0.159 | 0.85 (0.67–1.07) | 0.155 | |
| rs1428 | Codominant | CC | 109 | 142 | 1.00 | 1.00 | ||
| CA | 239 | 228 | 1.37 (1.00–1.86) | 0.048 | 1.37 (1.00–1.86) | 0.048 | ||
| AA | 165 | 138 | 1.56 (1.11–2.18) | 0.010 | 1.56 (1.11–2.19) | 0.010 | ||
| Dominant | CC | 109 | 142 | 1.00 | 1.00 | |||
| AA + CA | 404 | 366 | 1.44 (1.08–1.92) | 0.013 | 1.44 (1.08–1.92) | 0.013 | ||
| Recessive | CC + CA | 348 | 370 | 1.00 | 1.00 | |||
| AA | 165 | 138 | 1.27 (0.97–1.66) | 0.081 | 1.27 (0.97–1.67) | 0.081 | ||
| Additive | – | – | – | 1.24 (1.05–1.47) | 0.011 | 1.24 (1.05–1.47) | 0.011 |
SNP: Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% Confidence interval
p < 0.05 was considered statistically significant.