Table 4.
Tumor type stratification analysis of association between MIR17HG polymorphisms and colorectal cancer risk
| SNP–ID | Model | Genotype | Rectal cancer | Colon cancer | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
| rs7336610 | Allele | C | 213 | 514 | 1.00 | 199 | 514 | 1.00 | ||
| T | 275 | 504 | 1.32 (1.06–1.64) | 0.013 | 235 | 504 | 1.20 (0.96–1.51) | 0.106 | ||
| Codominant | CC | 47 | 142 | 1.00 | 50 | 142 | 1.00 | |||
| TC | 119 | 230 | 1.56 (1.05–2.33) | 0.028 | 99 | 230 | 1.23 (0.82–1.84) | 0.310 | ||
| TT | 78 | 137 | 1.72 (1.12–2.66) | 0.014 | 68 | 137 | 1.42 (0.92–2.19) | 0.119 | ||
| Dominant | CC | 47 | 142 | 1.00 | 50 | 142 | 1.00 | |||
| TT + TC | 197 | 367 | 1.62 (1.12–2.36) | 0.011 | 167 | 367 | 1.30 (0.90–1.89) | 0.168 | ||
| Recessive | CC + TC | 166 | 372 | 1.00 | 149 | 372 | 1.00 | |||
| TT | 78 | 137 | 1.28 (0.91–1.78) | 0.152 | 68 | 137 | 1.24 (0.87–1.75) | 0.229 | ||
| Additive | – | – | – | 1.30 (1.05–1.60) | 0.017 | – | – | 1.19 (0.96–1.47) | 0.120 | |
| rs7318578 | Allele | A | 359 | 717 | 1.00 | 311 | 717 | 1.00 | ||
| C | 125 | 303 | 0.82 (0.65–1.05) | 0.119 | 121 | 303 | 0.92 (0.72–1.18) | 0.516 | ||
| Codominant | AA | 135 | 245 | 1.00 | 111 | 245 | 1.00 | |||
| CA | 89 | 227 | 0.71 (0.51–0.98) | 0.038 | 89 | 227 | 0.88 (0.63–1.22) | 0.434 | ||
| CC | 18 | 38 | 0.86 (0.47–1.56) | 0.618 | 16 | 38 | 0.93 (0.50–1.75) | 0.828 | ||
| Dominant | AA | 135 | 245 | 1.00 | 111 | 245 | 1.00 | |||
| CC + CA | 107 | 283 | 0.73 (0.54–1.00) | 0.047 | 105 | 265 | 0.88 (0.64–1.22) | 0.449 | ||
| Recessive | AA + CA | 224 | 1.00 | 200 | 472 | 1.00 | ||||
| CC | 18 | 38 | 1.00 (0.56–1.79) | 0.994 | 16 | 38 | 0.99 (0.54–1.82) | 0.979 | ||
| Additive | – | – | – | 0.82 (0.64–1.05) | 0.113 | – | – | 0.92 (0.71–1.19) | 0.538 | |
| rs1428 | Allele | C | 212 | 512 | 1.00 | 199 | 512 | 1.00 | ||
| A | 274 | 504 | 1.31 (1.06–1.63) | 0.014 | 235 | 504 | 1.20 (0.96–1.50) | 0.113 | ||
| Codominant | CC | 47 | 142 | 1.00 | 50 | 142 | 1.00 | |||
| CA | 118 | 228 | 1.57 (1.05–2.33) | 0.027 | 99 | 228 | 1.24 (0.83–1.86) | 0.288 | ||
| AA | 78 | 138 | 1.71 (1.11–2.64) | 0.015 | 68 | 138 | 1.41 (0.91–2.17) | 0.125 | ||
| Dominant | CC | 47 | 142 | 1.00 | 50 | 142 | 1.00 | |||
| AA + CA | 196 | 366 | 1.62 (1.12–2.36) | 0.011 | 167 | 366 | 1.30 (0.90–1.89) | 0.162 | ||
| Recessive | CC + CA | 165 | 370 | 1.00 | 149 | 370 | 1.00 | |||
| AA | 78 | 138 | 1.27 (0.91–1.77) | 0.161 | 68 | 138 | 1.22 (0.86–1.73) | 0.256 | ||
| Additive | – | – | – | 1.29 (1.05–1.60) | 0.018 | – | – | 1.18 (0.95–1.47) | 0.127 | |
SNP: Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% Confidence interval
OR and 95% CI were calculated using logistic regression adjusted with age and gender.
p < 0.05 was considered statistically significant.