Table 5.
Gender stratification analysis of association between MIR17HG polymorphisms and colorectal cancer risk
| SNP‐ID | Model | Genotype | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
| rs7336610 | Allele | C | 263 | 304 | 1.00 | 261 | 236 | 1.00 | ||
| T | 309 | 268 | 1.33 (1.06–1.68) | 0.015 | 195 | 210 | 0.84 (0.65–1.09) | 0.192 | ||
| Codominant | CC | 66 | 88 | 1.00 | 76 | 67 | 1.00 | |||
| TC | 131 | 128 | 1.36 (0.91–2.04) | 0.130 | 109 | 102 | 0.94 (0.61–1.44) | 0.770 | ||
| TT | 89 | 70 | 1.70 (1.08–2.65) | 0.021 | 43 | 54 | 0.70 (0.42–1.18) | 0.177 | ||
| Dominant | CC | 66 | 88 | 1.00 | 76 | 67 | 1.00 | |||
| TT + TC | 220 | 198 | 1.48 (1.02–2.15) | 0.039 | 152 | 156 | 0.86 (0.58–1.27) | 0.443 | ||
| Recessive | CC + TC | 197 | 216 | 1.00 | 185 | 169 | 1.00 | |||
| TT | 89 | 70 | 1.39 (0.97–2.01) | 0.077 | 43 | 54 | 0.73 (0.46–1.14) | 0.166 | ||
| Additive | – | – | – | 1.30 (1.04–1.63) | 0.021 | – | – | 0.85 (0.65–1.09) | 0.199 | |
| rs7318578 | Allele | A | 413 | 394 | 1.00 | 340 | 323 | 1.00 | ||
| C | 155 | 178 | 0.83 (0.64–1.07) | 0.155 | 114 | 125 | 0.87 (0.64–1.17) | 0.342 | ||
| Codominant | AA | 152 | 128 | 1.00 | 125 | 117 | 1.00 | |||
| CA | 109 | 138 | 0.66 (0.47–0.94) | 0.020 | 90 | 89 | 0.95 (0.65–1.40) | 0.803 | ||
| CC | 23 | 20 | 0.97 (0.51–1.84) | 0.920 | 12 | 18 | 0.62 (0.29–1.35) | 0.231 | ||
| Dominant | AA | 152 | 128 | 1.00 | 125 | 117 | 1.00 | |||
| CC + CA | 132 | 158 | 0.70 (0.51–0.98) | 0.036 | 102 | 107 | 0.90 (0.62–1.30) | 0.563 | ||
| Recessive | AA + CA | 261 | 266 | 1.00 | 215 | 206 | 1.00 | |||
| CC | 23 | 20 | 1.17 (0.63–2.19) | 0.618 | 12 | 18 | 0.64 (0.30–1.36) | 0.242 | ||
| Additive | – | – | – | 0.82 (0.63–1.07) | 0.145 | – | – | 0.87 (0.64–1.17) | 0.346 | |
| rs17735387 | Allele | G | 477 | 457 | 1.00 | 382 | 371 | 1.00 | ||
| A | 95 | 115 | 0.79 (0.59–1.07) | 0.127 | 74 | 77 | 0.93 (0.66–1.32) | 0.699 | ||
| Codominant | GG | 203 | 181 | 1.00 | 158 | 154 | 1.00 | |||
| GA | 71 | 95 | 0.67 (0.46–0.96) | 0.031 | 66 | 63 | 1.02 (0.67–1.53) | 0.944 | ||
| AA | 12 | 10 | 1.07 (0.45–2.54) | 0.876 | 4 | 7 | 0.54 (0.15–1.88) | 0.331 | ||
| Dominant | GG | 203 | 181 | 1.00 | 158 | 154 | 1.00 | |||
| AA + GA | 83 | 105 | 0.70 (0.50–1.00) | 0.051 | 70 | 70 | 0.97 (0.65–1.44) | 0.872 | ||
| Recessive | GG + GA | 274 | 276 | 1.00 | 224 | 217 | 1.00 | |||
| AA | 12 | 10 | 1.21 (0.51–2.86) | 0.660 | 4 | 7 | 0.53 (0.15–1.86) | 0.325 | ||
| Additive | – | – | – | 0.80 (0.59–1.07) | 0.135 | – | – | 0.92 (0.65–1.32) | 0.661 | |
| rs1428 | Allele | C | 263 | 302 | 1.00 | 260 | 238 | 1.00 | ||
| A | 309 | 266 | 1.33 (1.06–1.68) | 0.015 | 194 | 210 | 0.85 (0.65–1.10) | 0.211 | ||
| Codominant | CC | 66 | 88 | 1.00 | 76 | 68 | 1.00 | |||
| CA | 131 | 126 | 1.39 (0.93–2.07) | 0.112 | 108 | 102 | 0.94 (0.62–1.44) | 0.788 | ||
| AA | 89 | 70 | 1.70 (1.08–2.65) | 0.021 | 43 | 54 | 0.71 (0.42–1.19) | 0.194 | ||
| Dominant | CC | 66 | 88 | 1.00 | 76 | 68 | 1.00 | |||
| AA + CA | 220 | 196 | 1.50 (1.03–2.17) | 0.034 | 151 | 156 | 0.86 (0.58–1.28) | 0.464 | ||
| Recessive | CC + CA | 197 | 214 | 1.00 | 184 | 170 | 1.00 | |||
| AA | 89 | 70 | 1.38 (0.96–2.00) | 0.086 | 43 | 54 | 0.73 (0.47–1.15) | 0.181 | ||
| Additive | – | – | – | 1.30 (1.04–1.63) | 0.021 | – | – | 0.85 (0.66–1.10) | 0.218 | |
SNP: Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% Confidence interval
OR and 95% CI were calculated using logistic regression adjusted with age and gender.
p < 0.05 was considered statistically significant.