Table 1.
Results of the most significant MR approach among those surviving Bonferroni multiple testing correction for each of the MR tests conducted
| Test | Method | SNP n | Estimate | P | Concordance | Het. (P > 0.05) | MR-Egger intercept (P > 0.1) |
|---|---|---|---|---|---|---|---|
| ACF→AD | Egger | 92 | −1.97 | 2.51×10−11 | pass | violated | violated |
| ACF×10−5→AD | Egger | 773 | −0.75 | 3.24×10−06 | pass | violated | violated |
| ACF×10−5→MD | IVW | 795 | 0.07 | 6.50×10−20 | violated | violated | violated |
| ACQ→AD | IVW | 31 | 0.12 | 3.81×10−11 | pass | violated | violated |
| ACQ→MD | IVW | 30 | 0.01 | 8.06×10−05 | violated | violated | pass |
| ACQ×10−5→AD | IVW | 385 | 0.06 | 7.34×10−20 | pass | violated | violated |
| ACQ×10−5→MD | IVW | 405 | 0.01 | 2.43×10−17 | violated | violated | violated |
| AD×10−5→ACF | Egger | 96 | −0.05 | 9.11×10−48 | pass | violated | violated |
| AD×10−5→ACQ | IVW | 95 | 0.26 | 3.26×10−36 | pass | violated | pass |
| MD→ACF | IVW | 36 | 0.05 | 4.06×10−08 | pass | violated | pass |
| MD→ACQ | Egger | 36 | −4.77 | 1.93×10−10 | pass | violated | violated |
| MD×10−5→ACF | IVW | 252 | 0.02 | 1.27×10−08 | violated | violated | pass |
| MD×10−5→ACQ | IVW | 251 | 0.31 | 1.46×10−06 | violated | violated | violated |
| MD×10−5→AD | IVW | 259 | 0.28 | 1.29×10−06 | pass | pass | pass |
ACF, alcohol consumption frequency; ACQ, alcohol consumption quantity; AD, alcohol dependence; MD, major depression; Het., heterogeneity test; suggestive loci (P < 5× 10−5). All top-results reported in the table were obtained using fixed effects and tophits adjustments (see online Supplemental Table S2)