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. 2019 Jun 13;9:8608. doi: 10.1038/s41598-019-44887-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Potency of drugs targeting the Cyt-bc₁:aa₃ is influenced by carbon metabolism. MIC₅₀ of Q203, ND-010885 and bedaquiline against M. tuberculosis H37Rv after 5 days (A,C,E) or 8 days (B,D,F) of incubation in the presence (red circles) or absence (green squares) of glycerol. Data are expressed as the mean ± SDs of triplicates for each concentration. Green dotted line: baseline for the dose-response curve without glycerol; red dotted line: baseline for the dose-response curve with glycerol.