Figure 2.

QcrB inhibitors are less than bacteriostatic against M. tuberculosis H37Rv on glycerol-supplemented medium. Potency of Q203 (A) and bedaquiline (B) against M. tuberculosis H37Rv growing in defined culture broth media supplemented with glycerol (red circles), glucose (green squares), pyruvate (blue triangles), acetate (purple diamonds) and propionate (pink hexagon) as sole carbon sources. MIC₅₀ were recorded after 10 days of incubation. (D–G) M. tuberculosis H37Rv was inoculated on defined culture broth media supplemented with glycerol (red circles), glucose (green squares), pyruvate (blue triangles), acetate (purple diamonds) and propionate (pink hexagon) as sole carbon sources without drugs (C), 100 nM of Q203 (D), 2000 nM of ND-10885 (E) 500 nM of bedaquiline (F), or at 1,000 nM of moxifloxacin (G). Bacterial growth was monitored over a 15 days period. Error bars represent the standard deviation (SD) of three biological replicates from a single experiment.