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. 2019 Jun 13;9:8592. doi: 10.1038/s41598-019-45023-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Patterns of protein expression changes induced by developmental hypoxic exposure in embryonic (E, 90% incubation) and juvenile (J, 2 y old) alligator hearts. (a) Differentially abundant proteins with p < 0.05 for the main effect of oxygen, where red are up-regulated and blue are down-regulated proteins, expressed as log2 fold change from the normoxic controls. (b) Differentially abundant proteins with p < 0.05 for the interaction effect of oxygen × age, where red traces are proteins with higher expression in embryonic than juvenile hearts, and blue traces indicate the opposite trend, in log2 fold change from normoxic controls. (c) Proportional representation of the 145 differentially abundant proteins, grouped as those with similar direction of response in embryonic and juvenile hearts (purple sections), those with opposite direction of response between the two ages (green sections), and those proteins that were uniquely regulated in a single treatment (grey sections).