Table 1.
Differentially abundant proteins for the main effect oxygen, where p < 0.05 and log2FC > |0.2|.
| Gene | Description | Function | log2FC | p |
|---|---|---|---|---|
| Up-regulated | ||||
| COPS2 | COP9 signalosome complex subunit 2 | regulates protein degradation | 0.274 | 0.016 |
| COX2 | Cytochrome oxidase subunit II | oxidative phosphorylation | 0.240 | 0.024 |
| ARHGDIA | Rho GDP-dissociation inhibitor 1 | regulates GTPase signalling | 0.226 | 0.017 |
| PSMD4 | Proteasome 26S subunit 4 | degradation of ubiquitinated proteins | 0.217 | 0.035 |
| MAIP1/C2orf47 | Matrix AAA peptidase interacting protein 1 | mitochondrial protease | 0.209 | 0.031 |
| MRPS29/DAP3 | Mitochondrial 28S ribosomal protein | translation; apoptosis | 0.203 | 0.030 |
| YWHAB | 14-3-3 alpha | intracellular signalling | 0.200 | 0.020 |
| Down-regulated | ||||
| FIS1 | Mitochondrial fission protein 1 | regulates mitochondrial morphology | −0.396 | 0.015 |
| (KYO27548.1) | No human ortholog | unknown | −0.377 | 0.026 |
| CRK | Adapter molecule crk | intracellular signalling | −0.365 | 0.021 |
| PPM1E | Protein phosphatase 1E | protein dephosphorylation, including CAMK | −0.340 | 0.032 |
| DYNC1LI2 | Dynein cytoplasmic 1 intermediate light chain 2 | microtubule-associated motor protein | −0.324 | 0.045 |
| SMS | Spermine synthase | catalyzes spermine production | −0.304 | 0.045 |
| STX12 | Syntaxin-12 | regulates protein transport | −0.265 | 0.034 |
| RTN1 | Reticulon-1 | membrane trafficking | −0.243 | 0.028 |
| CDK5RAP3 | CDK5 regulatory subunit-associated protein 3 | transcriptional regulation, cell cycle progression | −0.242 | 0.020 |
| GPD1L | Glycerol-3-phosphate dehydrogenase 1-like | regulates cardiac sodium current | −0.232 | 0.031 |
| TPMT | Thiopurine S-methyltransferase | thiopurine metabolism; endogenous function unknown | −0.211 | 0.011 |
| NRAP | Nebulin related anchoring protein | myofibrilar organization in cardiomyocytes | −0.210 | 0.033 |
| COA3 | Cytochrome c oxidase assembly factor 3 | mitochondrial assembly | −0.207 | 0.034 |
| SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase | regulates dNTP pool | −0.204 | 0.001 |
| ADHFE1 | Hydroxyacid-oxoacid transhydrogenase, mitochondrial | oxidoreductase activity | −0.202 | 0.003 |
Up-regulated and down-regulated proteins are presented separately, ordered by magnitude of log2FC. Where no human homolog was found and function was unknown, protein is listed by Accession number in place of gene symbol. FC = fold change.