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. 2019 Jun 13;10(6):465. doi: 10.1038/s41419-019-1712-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Subcutaneous tumorigenicity experiments in nude mice showed 28 days after cell injection, lower tumor weight, and volume was observed in Lv-AQP3-shRNAs groups compared with Lv-AQP3-NC groups (*P < 0.05, **P < 0.01). The subcutaneous tumors of nude mice were prepared into paraffin sections, IHC was used to test the protein levels of AQP3, CD133 and pY⁷⁰⁵-STAT3, results showed CD133 and pY⁷⁰⁵-STAT3 expression were decreased when AQP3 knockdown