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. 2019 Jun 13;10:2613. doi: 10.1038/s41467-019-10384-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Production of kistamicin intermediates in A. parvosata WT and Δoxy mutants. a A. parvosata wildtype (WT) produces kistamicin A, a tricyclic heptapeptide. b A. parvosata ΔoxyA (ΔkisN) produces several intermediates from kistamicin biosynthesis, including monocyclic hexa-/heptapeptides and different bicyclic hexapeptides (all structures contain the Tyr-6/ Hpg-4 C-O-D crosslink but display alternate off pathway cyclisation at the peptide N-terminus). c A. parvosata ΔoxyC (ΔkisO) produces only the linear hexa-/heptapeptide intermediates from kistamicin biosynthesis