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. 2019 Jun 13;10:2613. doi: 10.1038/s41467-019-10384-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Computational analysis of alternative A-B ring crosslinks. Comparison of the relative energies of kistamicin (containing the native 15-membered A-O-B ring and modelled as 1) relative to the energies of kistamicin analogues 2 and 3 which contain 13- and 12-membered AB rings, respectively. The ring derived from A-O-B crosslinking is significantly less stable than the smaller rings derived from AB crosslinking. Source data are provided as a Source Data file