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. 2019 Jun 13;9:8590. doi: 10.1038/s41598-019-45135-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional modules at baseline in SLE patients with early or late flare. (a,b) Activation of transcriptional modules was determined at baseline and compared between SLE patients with early flare (a; n = 21) or late flare (b; n = 13) versus healthy controls. Each box marked with a colored square represents a module, and the color of the square indicates the primary function of the module, as shown at the bottom of the figure. The size of each circle represents the absolute value of the module score. The color represents an increase (red circles; positive scores) or decrease (blue circles; negative scores) in the pathway, in patients compared to controls, as shown at right. P values were determined by non-parametric test. (c) The radar plot summarizes differences between the module scores in the early vs. late flare groups.