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. 2019 Jun 13;9:8620. doi: 10.1038/s41598-019-45134-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation study of oxidized albumin using a rat model of proteinuria and hypertension. (a) The systolic blood pressure of the UNx + NS group (n = 20), UNx + HS group (n = 18), and UNx + HST (n = 17) for 4 weeks. The values are shown as the AVE ± SEM. (b) The urinary protein level of the proteinuria and hypertension model. The UNx + NS group (n = 20), UNx + HS group (n = 18), and UNx + HST group (n = 17) were evaluated. The values are shown as the AVE ± SEM. (All urinary protein levels were logarithmically transformed prior to statistical analysis by ANOVA with Tukey’s post hoc test because they had a heteroscedastic distribution). (c) Oxidized albumin% of the proteinuria and hypertension model. The UNx + NS group (n = 20), UNx + HS group (n = 18), and UNx + HST group (n = 17) were evaluated. The values are shown as the AVE ± SEM. (d) The 8-isoprostane level of the proteinuria and hypertension model. The UNx + NS group (n = 20), UNx + HS group (n = 18), and UNx + HST group (n = 17) were evaluated. The values are shown as AVE ± SEM.