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. 2019 Jun 13;9:8609. doi: 10.1038/s41598-019-44950-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Response to etoposide is altered in SIAE over-expressing cells. RES256 cells were exposed to etoposide for 72 hours after 48 hours of induction with SIAE. No significant differences in response to drug were seen with induction of expression (induced expression is shown in grey) in EGFP, SIAE 1 or S127A (p > 0.05), however the IC₅₀ was significantly reduced from 5.1 μM (±1.3) to 1.9 μM (±0.9) in SIAE 2 (p = 0.0034). Data analysed using GraphPad Prism 6 software using sigmoidal dose-response comparison analysis. Data presented as mean ± SEM n = 3.