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. 2019 Jun 13;10:2602. doi: 10.1038/s41467-019-10475-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Schematic model for the PAQR-2 signaling-mediated longevity at low temperature. At low temperature, the adiponectin receptor PAQR-2 upregulates the expression of fat-7, which encodes a stearic CoA desaturase, by the nuclear receptor NHR-49 in worms. FAT-7 promotes the biosynthesis of two ω-6 PUFAs, γ-linolenic acid and arachidonic acid, which in turn induce autophagy. Increased autophagic activity in the epidermis delays an age-related decline in collagen contents to promote longevity