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. 2019 May 2;6:100032. doi: 10.1016/j.ynpai.2019.100032

Fig. 4.

Fig. 4

CatS inhibitors and PAR2 antagonist prevent activated Cat-S induced itch-like behaviour. A) Total sum behaviour over the 15 min observation period after intradermal injection of activated hr-CatS (20 µg/mouse) and 1 hr pre-treatment with LHVS (30 mg/kg s.c.). B) Total sum behaviour over the 15 min observation period after intradermal injection of activated hr-CatS (20 µg/mouse) and 1 hr pre-treatment with MDV-590 (200 µmol/kg p.o.). C) Total sum behaviour over the 15 min observation period after intradermal injection of activated hr-CatS (20 µg/mouse) and 1 hr pre-treatment FSLLRY (50 µg/ mouse, intradermal). D) Total sum behaviour over the 15 min observation period after intradermal injection of SLIRGL (50 µg/mouse) and 1 hr pre-treatment FSLLRY (50 µg/ mouse, intradermal); *P < 0.05, **P < 0.01 ***P < 0.001, One Way ANOVA followed by Dunnett’s test versus vehicle group. Data are mean + SEM of 8 animals per group.