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. 2019 May 16;12(6):1232–1241. doi: 10.1016/j.stemcr.2019.04.017

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Regulators of Inflammation Delivered by iPSC-CMs Infected with T. cruzi

(A–C) Sixty-three human molecules were measured in the supernatants of iPSC-CMs uninfected and infected with T. cruzi (Tc Y strain) (1:5, 3 h interaction). Graphs shows most significantly affected (A) pro-inflammatory cytokines, (B) cell trafficking regulators, and (C) regulatory cytokines produced by iPSC-CMs following 24 and 48 h T. cruzi infection. Significant statistical differences are indicated among samples (p < 0.05).

(D) Significant positive correlation between cytokines and chemokines produced by iPSC-CMs at 48 h T. cruzi infection (p < 0.05; Spearman and Pearson correlation). These results are averages of three different iPSC-CM lines, with each line being tested in duplicates.