Table 3.
Changes in perfusion parameters, RECIST-1.1 diameter, and tumour volume in patients with partial response, stable disease, and progressive disease (n = 53)
| Partial response (n = 30) | Stable disease (n = 20) | Progressive disease (n = 3) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | Control | p value | Baseline | Control | p value | Baseline | Control | p value | |
| Blood flow (mL/100 mL/min) | 162.0 ± 78.8 | 154.7 ± 90.2 | 0.681 | 234.0 ± 199.0 | 195.3 ± 111.8 | 0.391 | 171.7 ± 146.2 | 170.41 ± 130.3 | 0.968 |
| Blood volume (mL/100 mL) | 8.1 ± 3.1 | 6.4 ± 3.0 | 0.006 | 9.3 ± 4.9 | 7.9 ± 3.7 | 0.137 | 7.3 ± 2.8 | 7.3 ± 4.8 | 0.975 |
| Permeability (mL/100 mL/min) | 15.5 ± 5.7 | 13.9 ± 8.3 | 0.307 | 17.8 ± 11.3 | 16.5 ± 10.2 | 0.709 | 18.3 ± 6.5 | 17.7 ± 9.6 | 0.809 |
| Mean transit time (s) | 7.1 ± 3.1 | 5.8 ± 2.4 | 0.031 | 6.4 ± 4.1 | 5.8 ± 2.3 | 0.456 | 7.8 ± 3.5 | 7.0 ± 3.6 | 0.465 |
| RECIST-1.1 diameter (mm) | 59.8 ± 23.7 | 41.0 ± 18.0 | 0.000 | 55.7 ± 23.4 | 53.3 ± 23.2 | 0.007 | 58.7 ± 20.4 | 65.0 ± 26.2 | 0.210 |
| Tumour volume (cc) | 120.2 ± 154.0 | 44.6 ± 59.8 | 0.000 | 90.4 ± 122.3 | 64.3 ± 108.0 | 0.006 | 93.3 ± 73.4 | 126.7 ± 97.6 | 0.145 |
Significant p values are in bold
RECIST Response evaluation criteria in solid tumours