Fig. 2.

Schematic overview of C₁₉steroid biosynthesis in the adrenal. De-novo androgen biosynthesis in the zona reticularis of the adrenal proceeds via the classical Δ⁵ pathway. CYP11B1 activity leads to the formation of 11-oxygenated C₁₉ steroids. Major pathways are indicated by bold arrows and arrows are labelled with the major isoform of the enzyme responsible for the reaction. Active androgens are shown in black boxes.