Figure 1.

Increased FGFR Activity Enhances Oligodendroglia Generation While Reducing Neuronal Progenitors in the SVZ

(A–E) Coronal sections through the SVZ stained (red) for DLX2+ neural progenitors (A), DCX+ neuroblasts (B), OLIG2+ oligodendroglia (C), CC1+ OLs (D), and NG2+ oligo progenitors (E). DAPI counterstain (blue).

(F) Quantitation of differences in cell numbers relative to control shows large increases in oligodendroglia and decreases in neural progenitors. n ≥ 3, mean ± SEM; ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001.

CC, corpus callosum; St, striatum. Scale bars, 100 μm. See also Figure S1.