Figure 2.

Increased FGFR Activity Promotes Oligodendrogenesis at the Expense of Neurogenesis after Focal Demyelination

(A) Left: depiction of corpus callosum LPC injection. Right: at 6 days post-injection (DPI), myelin staining (MBP) (red) shows focal demyelination (arrow).

(B–D) Coronal sections through the SVZ at 14 days post-LPC stained (red) for DCX (B), OLIG2 (C), and DLX2 (D). Quantitation on the right shows decreased neuroblasts and neural progenitors with concurrent increased oligodendroglia on the injected ipsilateral side in mutants compared with controls.

LV, ventricle. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.