Figure 4.

Increased FGFR Activity Promotes OL Regeneration and Remyelination

(A) More new oligodendroglia (BrdU+ OLIG2+, arrows) are observed at sites of LPC demyelination in the corpus callosum 6 days post-injection in GOF mutants compared with controls.

(B) More OLs labeled by CC1 and myelinated axons labeled by NF1 and MBP viewed by confocal imaging in the corpus callosum and lower cortical layers (L. Ctx) at 10 days post-cuprizone are observed in the GOF mutants.

(C) Transmission electron micrographs showing sections through the corpus callosum with a greater number of myelinated axons in the GOF mutants than controls.

^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001. See also Figures S3 and S4.