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. 2019 May 17;18(1):605–613. doi: 10.3892/etm.2019.7590

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Copyright: © Jiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effects of miR-155 on brain endothelial BBB following cerebral I/R injury in mice. (A) Hematoxylin and eosin staining (magnification, ×40), (B) brain water content and (C) Evans blue staining were quantified as indications of BBB integrity at 24 h following MCAO (n=5). (D) NO levels in brains were tested at 24 h following MCAO (n=5). (E) Western blot analysis of the eNOS protein levels in brains at 24 h following MCAO (n=5). Data are expressed as the mean ± standard deviation. *P<0.05, **P<0.01, ***P<0.001. miR, microRNA; BBB, blood-brain barrier; I/R, ischemia reperfusion; MCAO, middle cerebral arterial occlusion; NO, nitric oxide; eNOS, endothelial NO synthase; miR-155^−/−, miR-155 inhibitor; miR-155^+/+, miR-155 mimics.