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. 2019 May 17;18(1):605–613. doi: 10.3892/etm.2019.7590

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Copyright: © Jiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effects of miR-155 on apoptosis following cerebral I/R injury in mice. (A) TUNEL staining (magnification, ×200) demonstrated the neuronal apoptosis following cerebral I/R injury (n=5). Apoptotic cell death was detected using a TUNEL staining kit. The green staining indicated TUNEL-positive cells and the blue staining indicated cell nucleus. (B) Western blot analysis of the caspase-3 protein levels in mouse brains at 24 h following middle cerebral arterial occlusion (n=5). Data are expressed as the mean ± standard deviation. **P<0.01, ***P<0.001; ^###P<0.001 vs. sham. miR, microRNA; I/R, ischemia reperfusion; miR-155^−/−, miR-155 inhibitor; miR-155^+/+, miR-155 mimics; TUNEL, terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling.