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. 2019 Apr 24;18(1):389–396. doi: 10.3892/etm.2019.7527

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Copyright: © Fei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — miR-18 inhibits insulin production by islet β-cells. (A) Reverse transcription-quantitative polymerase chain reaction analysis indicated that miR-18 mimics caused a downregulation of pro-insulin levels in MIN6 cells. (B) miR-18 mimics caused a reduction of released insulin levels as detected by ELISA. (C) miR-18 knockdown partially abrogated the IL-1β-induced decrease in the levels of pro-insulin. (D) A glucose-stimulated insulin secretion assay indicated the inhibitory effect of miR-18 on insulin secretion. (E) The suppressed insulin secretion capacity in IL-1β-induced MIN6 cells was partially abrogated by miR-18 knockdown. *P<0.05. miR, microRNA; IL, interleukin; NC, negative control.