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. 2019 Apr 24;18(1):389–396. doi: 10.3892/etm.2019.7527

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Copyright: © Fei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — miR-18 promotes apoptosis of islet β-cells. (A) A TUNEL assay indicated that miR-18 mimics promoted apoptosis of islet β-cells, whereas miR-18 knockdown achieved the opposite result (magnification, ×100). Western blot analysis indicated that transfection of miR-18 mimics into MIN6 cells (B) markedly upregulated the pro-apoptotic gene Bax and (C) downregulated the anti-apoptotic gene Bcl-2. *P<0.05. miR, microRNA; TUNEL, terminal deoxynucleotidyl transferase-mediated deoxyuridinetriphosphate nick end labeling; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein; NC, negative control.