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. 2019 May 23;18(1):550–558. doi: 10.3892/etm.2019.7601

Figure 4.

Figure 4.

miR-620 directly regulates DCTD expression levels by binding to its 3′-UTR. (A) Sequence alignment of the human DCTD mRNA 3′-UTR and complementary miR-620 sequence. 293 cells were cotransfected with DCTD 3′-UTR-WT or DCTD 3′-UTR-Mut and miR-620 mimics or miR-NC mimics. (B) The luciferase activity of cells transfected with DCTD 3′-UTR-WT and miR-620 mimics was significantly reduced compared with cells transfected with DCTD 3′-UTR-WT and miR-NC mimics. **P<0.01 vs. the DCTD 3′-UTR-WT miR-NC group. miR, microRNA; UTR, untranslated region; WT, wild-type; Mut, mutant; NC, negative control.