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. 2019 May 23;18(1):550–558. doi: 10.3892/etm.2019.7601

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — miR-620 inhibition or overexpression of DCTD reverses gemcitabine resistance of MDA-MB-231rGEM1 cells. (A) Compared with cells transfected with pcDNA3, transfection of pcDNA3-DCTD markedly increased DCTD protein expression levels in MDA-MB-231rGEM1 cells. (B) Transfection with miR-620 inhibitor or pcDNA3-DCTD sensitized MDA-MB-231rGEM1 towards gemcitabine treatment by inhibiting cell proliferation. **P<0.01 vs. gemcitabine + miR-NC inhibitor + pcDNA3. (C) Transfection of miR-620 inhibitor or pcDNA3-DCTD sensitized MDA-MB-231rGEM1 towards gemcitabine treatment by inducing cell apoptosis. (D) Quantitative analysis of cell apoptosis. ***P<0.001 as indicated. miR, microRNA; NC, negative control; PI, propidium iodide.