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. 2019 Feb 11;25(7):825–836. doi: 10.1111/cns.13105

Figure 1.

Figure 1

The Tim and Tom complexes. The key pore proteins are Tom40 and Tim23, for the OMM and the IMM, respectively. In the Tom complex, smaller subunits Tom5, Tom6, and Tom7 are within the OMM. Larger subunits Tom20, Tom22, Tom37, Tom70, and Tom71 are receptor proteins, which bind to proteins and guide them into the IMS. The main Tim complex is comprised of additional subunits Tim11, Tim17, and Tim44. Proteins enter to the matrix via the Tom and Tim complexes. Proteins such as alpha‐synuclein bind to the receptor Tom20, which then guides them into the Tom40 pore (blue line)