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. 2019 May 7;18(1):77–84. doi: 10.3892/etm.2019.7552

Figure 3.

Figure 3.

IGF1R is a target of miR-15b. (A) Binding sites between miR-15b and the 3′UTR of IGF1R were predicted via TargetScan software. (B) The luciferase activity of reporters containing the WT-IGF1R 3′UTR or MUT-IGF1R 3′UTR are presented. **P<0.01 vs. the mimic control. Relative (C) mRNA and (D) protein levels of IGF1R in hVSMCs were determined via reverse transcription-quantitative polymerase chain reaction and western blotting, respectively. Tests were performed 48 h following transfection with miR-15b mimics, mimic controls, miR-15b inhibitors or inhibitor controls. All data are presented as the mean ± standard deviation. **P<0.01 vs. the control. IGF1R, insulin growth factor 1 receptor; miR, microRNA; UTR, untranslated region; WT, wild-type; MUT, mutant.