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. 2019 May 23;18(1):664–670. doi: 10.3892/etm.2019.7606

Figure 2.

Figure 2.

HMGA2 is a direct target gene of miR-490-3p in glioma. (A) Bioinformatics analysis was used to predict the miR-490-3p target sequence in the 3′-UTR of HMGA2. (B) Luciferase reporter assays were performed in cells following co-transfection with wt or mut 3′-UTR HMGA2 and miR-490-3p mimic or NC-miRNA. (C) The relative HMGA2 protein expression was determined by western blot analysis in cells following transfection with miR-490-3p mimic or NC-miRNA. (D) Correlation analysis of miR-490-3p and HMGA2 in glioma. ***P<0.001 vs. NC-miRNA. ns, not significant; miR-490-3p, microRNA-490-3p; wt, wild-type; mut, mutant; NC, negative control; UTR, untranslated region; HMGA2, high-mobility group AT-hook 2.