Table 1.
Overview of prediction methods for peptide solubility and cell-penetrating peptides.
| Method | Learning Machine Model | Input Length (aa) | Input Format | Multiple Entry | Database | Web Server | Refs |
|---|---|---|---|---|---|---|---|
| Peptide Solubility | |||||||
| ccSOL omics | Super vector machine (SVM) | – | FASTA | Yes (up to 104) | Target Track (non-redundant) (http://sbkb.org/tt/) | http://s.tartaglialab.com/static_files/shared/tutorial_ccsol_omics.html | [39] |
| PROSO II | Super vector machine (SVM) | 21 to 2000 | FASTA | Yes (up to 50) | Target Track (http://sbkb.org/tt/) | http://mbiljj45.bio.med.uni-muenchen.de:8888/prosoII/prosoII.seam | [40] |
| Cell-Penetrating Peptides | |||||||
| CPPpred | Artificial neural networks (ANN) | 5 to 30 | FASTA | Yes | CPPsite | http://bioware.ucd.ie/cpppred | [47] |
| CPPpred-RF | Random forest (RF) | – | FASTA | Yes | CPP924 and CPPsite3 | http://server.malab.cn/CPPred-RF | [46] |
| KELM-CPPpred | Kernel extreme learning model (KELM) | 5 to 30 | FASTA | Yes | Curated 408 CPP/non-CPP | http://sairam.people.iitgn.ac.in/KELM-CPPpred.html | [48] |
| CellPPD | Super vector machine (SVM) | – | FASTA | Yes | CPPsite1,2,3 | http://crdd.osdd.net/raghava/cellppd/multi_pep.php | [50] |
| CPPsite 2.0 | – | – | FASTA | Yes | 1855 uniquely curated | http://crdd.osdd.net/raghava/cppsite/ | [51] |