Table 2.

Baseline and three-month changes in safety laboratory variables by group allocation.

	Nutraceutical Combination (n = 20)	Placebo (n = 20)	p †
Glucose, mmol/L
Baseline	5.1 (4.7 to 5.5)	5.0 (4.7 to 5.4)	0.314
Change *	−0.28 (−0.26 to 0.37)	0.05 (−0.08 to 0.44)	0.341
Creatinine, μmol/L
Baseline	0.70 (0.64 to 0.85)	0.71 (0.66 to 0.85)	0.758
Change	0.38 (−3.05 to 5.71)	0.01 (−2.28 to 5.33)	0.327
AST, μkat/L
Baseline	0.358 (0.337 to 0.395)	0.317 (0.283 to 0.367)	0.096
Change	0.02 (−0.03 to 0.03)	0.01 (−0.05 to 0.07)	0.883
ALT, μkat/L
Baseline	0.325 (0.235 to 0.445)	0.283 (0.233 to 0.358)	0.414
Change	0.001 (−0.07 to 0.05)	0.001 (−0.04 to 0.08)	0.904
GGT, μkat/L
Baseline	0.292 (0.250 to 0.608)	0.283 (0.233 to 0.525)	0.863
Change	−0.02 (−0.06 to 0.01)	−0.02 (−0.07 to 0.05)	0.799
LDH, μkat/L
Baseline	2.867 (2.572 to 3.283)	2.950 (2.683 to 3.383)	0.863
Change	0.03 (−0.08 to 0.20)	−0.02 (−0.26 to 0.21)	0.311
CK, μkat/L
Baseline	1.600 (1.353 to 1.958)	1.383 (1.058 to 1.700)	0.157
Change	0.06 (−0.17 to 0.23)	−0.13 (−0.41 to 0.16)	0.253
Aldolase, μkat/L
Baseline	0.063 (0.045 to 0.080)	0.057 (0.048 to 0.072)	0.708
Change	−0.01 (−0.02 to 0.02)	0.01 (−0.02 to 0.02)	0.568

Values are medians (interquartile range). AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma glutamyl transpeptidase; LDH: Lactate dehydrogenase; CK: Creatine kinase. * p value for comparisons between baseline and three months with the Wilcoxon T test. ^† p value for comparisons between groups with the Mann–Whitney U test for continuous variables.