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. 2019 May 20;20(10):2489. doi: 10.3390/ijms20102489

Figure 4.

Figure 4

Effects of Ebselen and compounds on p-c-Met, p-AKT and p-ERK in EBC-1 cancer cells. (A) Western blot analysis in the EBC-1 cells treated with concentrations near the IC50 values of compounds for 4 h. Ebselen was unable to inhibit the phosphorylation of c-Met at 25 μM. (B) Representative Western blot analysis in the EBC-1 cells treated with increasing concentrations of compounds 3d, 7a, 7b, 8b and 12c, as indicated. All of the tested compounds could inhibit the phosphorylation of Met, AKT and ERK in a dose-dependent manner.