Table 1.
Characteristics of different ovarian cancer histological types.
| Clinical Characteristics | High-grade Serous | Low-grade Serous | Clear Cell | Endometrioid | Mucinous |
|---|---|---|---|---|---|
| Prevalence | 65%–70% | 3% | 5%–10% | 10%–15% | 2%–8% |
| Hereditary risk | 18%–20% present germline BRCA1/2 mutations | unknown | unknown | 10%–14% endometrioid tumors are associated with HNPCC syndrome | unknown |
| Stage at diagnosis | Advanced | Early Advanced |
Early | Early | Early |
| Genetic alterations | p53 p16 pRb pathway Homologous recombination defects (BRCA1/2, RAD51) |
BRAF or KRAS |
HNF-1β IL6/JAK2/STAT3 PI3K MSI ARID1A |
PTEN β-Catenin KRAS MSI ARID1A |
K-ras c-MYC HER2 |
| Chemotherapy response | 80% | 26–28% | 15% | unknown | 15% |
| Immune infiltrate | High, more commonly associated with BRCA1 defects | Low | Generally low, higher when associated with MSI | Generally low, higher when associated with MSI | Low |