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. 2019 May 27;20(10):2597. doi: 10.3390/ijms20102597

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CCL19-mediated calcium mobilization and CCR7 endocytosis are not affected by Nb1, Nb5, or Nb38. (a) Influence of intracellular expression of the CCR7-recognizing Nbs, Nb1, Nb5, and Nb38, on CCL19-mediated changes in intracellular calcium concentrations was measured in H1299 cells stably expressing CCR7-HA. Cells were stimulated with 0.5 µg/mL of CCL19. A representative experiment out of three is shown. (b) Endocytosis of CCR7 triggered by 1 µg/mL CCL19 was analyzed in HEK293-CCR7-HA cells transiently expressing CCR7-recognizing Nbs. Co-expressing EYFP or Nb80 instead of CCR7-recognizing Nbs served as controls. Mean values and SEM out of three independent experiments are presented.