Table 2.
Role of phenolic acids on cell migration and angiogenesis.
| Reference | Model | Fraction(s) | Source | Concentration | Overall Effect |
|---|---|---|---|---|---|
| Park, J., et al. (2015) [86] | HUVECs | Chlorogenic Acid | Commercially obtained | 2 and 10 μM | Anti-angiogenesis |
| Lin, C.M., et al. (2010) [87] | HUVECs CAM |
Ferulic acid | Commercially obtained | (10−6–10−4 M) (10−6–10−5 M) |
Pro-angiogenesis |
| Kong, C., et al. (2013) [88] | ECV304 cells Sprague-Dawley Rats |
p-Coumaric Acid | Commercially obtained | 0.5 and 1 mM | Anti-angiogenesis |
| Sousa, M., et al. (2016) [89] | HMVECs | Total Phenolic Extract | Red Raspberries | 10, 25, 50 and 100 μg GAE/mL | Anti-angiogenesis |
| Vuthijumnonk, J., et al. (2015) [83] | CAM | Chlorogenic Acid | Rabbit-eye Blueberry | 30 μL from 180 mL crude extract | Pro-angiogenesis |
| Tsakiroglou, P., et al., (2019) [85] | HUVEC Ibidi wound healing assay |
Phenolic acid fraction | Wild blueberry | 0.002, 8, 15, 60 and 120 μg/mL | Pro-angiogenesis |
HUVECs: Human umbilical vein endothelial cells; HMVECs: Human microvascular endothelial cells; CAM: Chick Chorioallantoic Membrane.