Figure 1.

Experimental schedule. (A) Experiment I: Male Wistar/ST rats (6 weeks old) were allocated to two groups (n = 10 each), one of which was injected with streptozotocin (STZ) (Groups III and IV) and the other with citrate buffer only (Groups I and II) for 7 days. Each group was further divided into two subgroups (n = 5 each), one of which was administered green tea (Groups II and IV), while the other drank only water (Groups I and III). During the feeding period, body weight and blood glucose concentration were measured on Days 0, 7, 10, and 13. Then the rats were killed on Day 19. (B) Experiment II: KK-A^y mice (4 weeks old) were allocated to three groups (n = 7 each) on Day 0. Group A received water from the first day on, Group B received green tea from the first day on, and Group C received green tea from Day 21 on, after the appearance of hyperglycemia. During the feeding period, body weight and blood glucose concentration were measured weekly, and the mice were sacrificed on Day 63.