Table 2.
Competing risk of stroke in patients with cancer and noncancer matched controls.
| Variables | Cancer | Non-cancer matched control | Subdistribution hazard ratio | 95 % CI | p-value |
|---|---|---|---|---|---|
| (N = 25920) | (N = 51840) | ||||
| Cancer | — | — | 1.72 | 1.48 to 2.01 | <0.0001† |
| Age, year* | 60.6 ± 15.2 | 60.6 ± 15.2 | 1.04 | 1.03 to 1.05 | <0.0001† |
| Sex (male)* | 13939 (53.8%) | 27878 (53.8%) | 1.22 | 1.04 to 1.43 | 0.013† |
| Hypertension* | 11135 (43.0%) | 22270 (43.0%) | 1.95 | 1.60 to 2.38 | <0.0001† |
| Diabetes mellitus* | 6188 (23.9%) | 12376 (23.9%) | 1.41 | 1.19 to 1.67 | <0.0001† |
| Chronic kidney disease* | 625 (2.4%) | 1250 (2.4%) | 0.98 | 0.68 to 1.41 | 0.900 |
| Atrial fibrillation* | 211 (0.8%) | 422 (0.8%) | 2.13 | 1.42 to 3.20 | <0.001† |
| Coronary artery disease | 3817 (14.7%) | 7211 (13.9%) | 1.11 | 0.92 to 1.34 | 0.260 |
| Heart failure | 1689 (6.5%) | 2748 (5.3%) | 1.49 | 1.19 to 1.86 | <0.001† |
| Hyperlipidemia | 7688 (29.7%) | 15061 (29.1%) | 0.97 | 0.82 to 1.15 | 0.749 |
| COPD | 5637 (21.8%) | 8591 (16.6%) | 1.02 | 0.86 to 1.21 | 0.834 |
| Alcohol overuse | 905 (3.5%) | 687 (1.3%) | 1.76 | 1.16 to 2.66 | 0.008† |
In the subdistributional proportional hazards model, all-cause mortality was considered a competing risk.
*
These comorbidities were matching criteria of patients with cancer and non-cancer matched controls.
†
p value < 0.05 was statistically significant. CI, confidence interval; COPD, chronic obstructive pulmonary disease.