Table 2.

Outcomes of small-study effect and meta-regression.

Outcome	Small-Study Effect		Meta-Regression by Duration			Meta-Regression by Single-eye Data			Meta-Regression by Type of Schirmer Test
	Egger test	P	Point Estimate	P	τ 2	Point Estimate	P	τ 2	Point Estimate	P	τ 2
TBUT	−0.53	0.81	−0.20	<0.001	1.62	0.17	0.55	2.16	NE	NE	NE
Schirmer test scores	−0.08	0.81	−0.05	0.17	0.00	−0.17	0.52	0.00	−0.31	0.26	0.00
Osmolarity	−2.83	0.32	NE	NE	NE	NE	NE	NE	NE	NE	NE
OSDI score	−3.18	0.05	0.54	0.03	15.27	NE	NE	NE	NE	NE	NE

OSDI: ocular surface disease index. TBUT: tear breakup time. NE, not estimate.