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. 2019 May 4;9(5):696. doi: 10.3390/nano9050696

Table 5.

Methods and techniques useful to implement the identified criteria in decision-support tools and systems.

# Typology/Sector Criteria Method-Technique-Action and Description
1 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Multi-Attribute Value Theory (MAVT): MCDA methodology that uses Value (Utility) functions to identify the most preferred alternative or to rank order the alternatives
2 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Outranking methods: They are based on the concept that an alternative may be dominant, with a certain degree, over another one
3 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Multi-objective optimization: An area of MCDA concerned with mathematical optimization problems involving more than one objective function to be optimized simultaneously
4 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Analytic hierarchy process (AHP): MCDA methodology that uses decomposition of the decision problem into a hierarchy of subproblems and evaluation of the relative importance of its various elements by pairwise comparisons
5 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Fuzzy logic: Introduces a formalization of vagueness and the notion of a degree of satisfaction of an object instead of an absolute evaluation
6 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Decision trees (decision analysis): A tool to model decisions, outcomes chances, and their possible consequences
7 Decision Analysis/MCDA methodologies C1, C2, C3, C4, C5, C6, C7, C8, C9 Value of Information (VoI): A methodology that can be used in tiers to explore uncertainty in risk assessment and decision-making
8 Decision Analysis/Mental modeling C9 Stakeholder profiling/need identification: The process of collecting and reviewing the opinions of relevant stakeholders with respect to the features, capabilities, usability of a decision-support tool
9 Decision Analysis/Mental modeling C9 Interviews/Focus Groups/Influence diagrams: Different techniques to perform mental modeling methodologies and present results
10 Decision Analysis/Software development C2, C6, C7 Decision-Support Systems: Building dedicating software for supporting decision-making
11 Risk Assessment-Management/Models C3, C5 Link-integration of models: Link or integration of various types of models (e.g., ERA-HH-exposure read-across grouping) in a decision-support tool
12 Risk Assessment-Management/Models C3, C5 Full life cycle/Cooper Stage Gate: Models and tools to cover the full life cycle (ERA, HH, LCIA, Social, EA, Risk Control) and connected to Cooper Stage Gate model. Provide multiple options for the user
13 Risk Assessment-Management/Risk management Measures C2, C3, C6 Types of Risk Management measures: Link-Integration of RMMs (e.g., Inventory of Technological Alternatives and Risk Management Measures (TARMMs), personalized risk management measures defined by the user or connection to the Exposure Control Efficacy Library (ECEL) database)
14 Risk Assessment-Management/Usability C1, C2, C3, C4, C5, C7, C8 Automatic conversion system: Introduction of an automatic conversion system, to improve usability of the system
15 Risk Assessment-Management/Usability C1, C2, C3, C4, C5, C7, C8 Quantal data: Support for quantal data in Human Health Hazard Assessment
16 Risk Assessment-Management/Usability C1, C2, C3, C4, C5, C7, C8 Nano-specific ontologies: A formal way to describe taxonomies and classification networks, essentially defining the structure of knowledge for various domains, they can be represented and shared through the recognized standard Web Ontology Language
17 Risk Assessment-Management/Usability C1, C2, C3, C4, C5, C7, C8 Assessment tree interface: Visual flow of sections (tiered approach/connected lifecycle models)
18 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Multiple interfaces: Web application accessible from any web browser, which can also be downloaded and installed in an intranet server. Also supports solutions to the confidentiality issue
19 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Graphical User Interfaces (GUIs): Minimum requirement for modern software-tools
20 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Bugs tracking system: Dedicated system, for efficiently improving Decision-Support Tools
21 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Feature request system: Dedicated system, for efficiently improving Decision-Support Tools
22 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Hosting environment: A crucial component for embedding models in a decision-support tool and allowing smooth operations for the user
23 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Appearance and usability of the web application: Smartly designed applications allow increased user-friendliness and improve risk/uncertainty communication
24 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Public pages: System users can select information for public viewing, allowing communication and partnerships with other stakeholders
25 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Data extraction/migration/interoperability features: Various import, migration, and export features increase user-friendliness of the systems and interoperability
26 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Easy registration/Multiple login methods: Improved usability of a system through multiple ways of identifying users and allowing them to register to the system
27 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Manual/Wiki: User guides in the form of a manual document or documented wiki pages can be used as technical communication documents
28 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Guidance: Interactive guidance of the user to the functionalities of a system
29 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 User communication: Systems can use different types of communication protocols for informing users
30 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Case study examples: Documented applications available to the user for experimentation and information sharing
31 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Pairing of functionalities with stakeholder profiling: Driving software developments by implementing identified features through the mental modeling processes
32 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Expandable system (modular): System designed to handle multiple material and needs in the future
33 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Data gaps: Cover lack of data with modeling techniques
34 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 API communication: Software to software communication
35 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Type of portal: HUB vs Integrated software
36 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Models: Basic characteristics of models for decision support: Multiple, Fast, Tailored, Embedded, Peer-reviewed, Integrated, Well-known
37 Software development/Features C1, C2, C3, C4, C5, C6, C7, C8, C9 Public projects: Availability of results to communities
38 Statistical methods/Methodology C1, C5 Decision Trees (machine learning): A method that uses a tree-like model of decisions and their possible consequences for identifying a strategy most likely to reach a goal
39 Statistical methods/Methodology C1, C5 Random forests: An ensemble learning method for classification, regression, and other tasks that operates by constructing a multitude of decision trees
40 Statistical methods/Methodology C1, C5 Sensitivity analysis: Evaluates the effect of changes in input values or assumptions on a model’s results
41 Statistical methods/Methodology C1, C5 Uncertainty analysis: Investigates the effects of lack of knowledge and other potential sources of error in the model
42 Statistical methods/Methodology C1, C5 Logistic regression: A predictive regression analysis that can be used to describe data and to explain the relationship between one dependent variable and one or more independent variables
43 Statistical methods/Methodology C1, C5 Neural networks: An alternative to regression models and other related statistical techniques in the areas of statistical prediction and classification
44 Statistical methods/Methodology C1, C5 Stable results: Calibration of models to be used in decision-support activities (sensitivity analysis and performance testing)