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. 2019 May 20;20(10):2493. doi: 10.3390/ijms20102493

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The expression of melanogenesis-related genes and melanogenesis were increased by the overexpression of Slc7a11. An extremly significant difference was signified with “**” (p < 0.01), and a significant difference was signified with “*” (p < 0.05). (a) Fluorescence detection results of pEGFP-N1-Slc7a11 transfected melanocytes. pEGFP-N1 was used as a control. (b) Detection of the overexpression of Slc7a11 in melanocytes by Real-time PCR. (c) The effect of Slc7a11 overexpression on the expression of pigmentation-related genes such as MITF, TYR, TYRP1, CREB1, and ASIP. (d) Detection of the expressions of MITF, TYR, and Slc7a11 (xCT) proteins in melanocytes by Wes. The relative expression levels of MITF, TYR, and Slc7a11 (xCT) proteins were calculated and analyzed using the Compass program. (e) The effect of Slc7a11 overexpression on melanogenesis in melanocytes. Melanocytes were collected after siRNA-3 transfection and the melanin level was measured using a microplate reader. (f) Melanocyte apoptosis rate was determined after overexpression of Slc7a11.