Table 1.

List of endocrine adverse events and recommendations.

		Hypophysitis	Hypothyroidism	Hyperthyroidism	Adrenalitis
Grade 1	Clinical symptoms	✓ Asymptomatic or mild symptoms	✓ Asymptomatic or mild symptoms	✓ Absence of symptoms	✓ Absence of symptoms
	Clinical management strategies	✓ Intervention not indicated	✓ Intervention not indicated	✓ Intervention not indicated	✓ Intervention not indicated
Grade 2	Clinical symptoms	✓ Mild symptoms such as headache, mood changes and fatigue ✓ Depending on age, mild impairment of the Instrumental Activities of Daily Living	✓ Symptomatic	✓ Symptomatic	✓ Moderate symptoms
	Clinical management strategies	✓ Minimal, local or noninvasive intervention indicated	✓ Mild impairment of the Instrumental Activities of Daily Living ✓ Thyroid replacement indicated	✓ It’s recommended thyroid suppression therapy ✓ Limiting instrumental ADL	✓ Medical intervention indicated
Grade 3	Clinical symptoms	✓ The disability can limit self care ✓ Severe or medically significant but not immediately life-threatening	✓ Self care limitation that affects the Activities of Daily Living ✓ Severe symptoms	✓ Self care limitation that affects the Activities of Daily Living ✓ Severe symptoms	✓ Severe symptoms
	Clinical management strategies	✓ Hospitalization or prolongation of existing hospitalization indicated	✓ Hospitalization recommended	✓ Hospitalization recommended	✓ Hospitalization recommended
Grade 4	Clinical symptoms	✓ Life-threatening consequences	✓ Life-threatening consequences	✓ Life-threatening consequences	✓ Life-threatening consequences
	Clinical management strategies	✓ Urgent intervention recommended	✓ Urgent intervention recommended	✓ Urgent intervention recommended	✓ Urgent intervention recommended
Grade 5		✓ Death	✓ Death	✓ Death	✓ Death

The National Cancer Institute has recommended that adverse events on patients with cancer chemotherapy be graded as per the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0.