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. 2019 May 22;9(5):787. doi: 10.3390/nano9050787

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genes involved in epigenetic and transcriptional regulation are significantly altered by PdNPs treatment. (A) Bar graphs showing GO terms enriched in downregulated genes. -log₁₀ (p-value) is used. (B) Representative heatmaps showing genes in the chromatin silencing at ribosomal DNA and nucleosome assembly GO terms. Note that most of the genes in the GO terms are associated with histone gene clusters. (C) Bar graphs showing GO terms enriched in upregulated genes. (D) Representative heatmaps showing genes in the GO terms of positive regulation of transcription from RNA polymerase II promoter and regulation of cell death.