Figure 3.

Effect of HLJG0701 on memory deficit in training sessions involving the Morris water maze task. To evaluate the effect of memory improvement, (A) the escape latency and (B) swimming distance to reach the platform were measured in training sessions during 5 consecutive days. Vehicle (control and negative groups, p.o.), HLJG0701 (p.o.), and donepezil (DPZ, positive group, i.p.) were treated and memory impairment was induced by scopolamine (SCO, i.p.). Data are expressed as mean ± SEM (n = 8). ^# p < 0.05, ^## p < 0.01 vs. control group, ^* p < 0.05, ^** p < 0.01 vs. negative group. (C) Representative images tracking the swimming movement on day 1, 3, and 5 in training sessions. The red curve tracks the movement of mice and the last location of mice is marked with the red square. The black circle indicates an escape platform.