Table 1.

Clinical efficacy of curcumin supplementation in osteoarthritis

Study	Study Design	No. of Patients	Study Duration (weeks)	Medications	Daily Curcuminoid Intake (mg/day)	Clinical Outcomes in Curcumin Group	Laboratory Outcomes in Curcumin Group
2018 Haroyan [9]	DB, PC, RCT	66	12		1500	↑ Walk speed ↓WOMAC, TUG time	N/A
2016 Srivastava [10]	DB, PC, RCT	160	16	NSAID continued	500	↓ VAS, WOMAC	↓ IL-1B, ROS, MDA
2016 Panahi [11]	DB, PC, RCT	40	6		1500	N/A	↑ GSH, SOD↓ MDA
2016 Sterzi S [12]	DB, PC, RCT	53	12		100	⇄ Knee ROM. ↓ LPFI, VAS	⇄ Inflammatory markers
2015 Rahimnia [13]	DB, PC, RCT	40	40		1500	N/A	⇄ Inflammatory markers
2014 Panahi [14]	DB, PC, RCT	40	6		1500	↓ LPFI, VAS, WOMAC	N/A
2014 Nakagawa [15]	DB, PC, RCT	50	8	NSAID continued	180	↓ Celecoxib use, VAS	N/A
2014 Kuptniratsaikul [16]	DB, RCT	367	4	NSAID continued	1500	↑ PhyGA. ↓ GI AE, WOMAC	N/A
2014 Belcaro [17]	OBS, PC	124	16		500	↑ Walking distance. ↓ Karnofsky, WOMAC, general pain	N/A
2013 Madhu [18]	SB, PC, RCT	120	6		1000	↓VAS, WOMAC, CGIC	N/A
2013 Kizhakkedath [19]	PC, RCT	30	12	NSAID continued	500	↑ Walk distance.↓ Joint tenderness, Crepitus, Knee ROM	⇄ Hemogram measurement, RFT
2012 Pinsornsak [20]	DB, PC, RCT,	88	12	NSAID continued as needed	1000	⇄ KOOS, VAS	N/A
2010 Belcaro [21]	DB, PC, RCT	50	12		200	↑ Walk distance. ↓ WOMAC	↓ CRP
2010 Belcaro [22]	DB, PC, RCT	100	32	NSAID continued as needed	200	↑ Walk distance, mobility, Karnofsky. ↓ NSAID use, WOMAC	↓ ESR, IL-1B, IL-6, sCD40L, sVCAM-1
2009 Kuptniratsaikul [23]	PC, RCT	107	6		2000	↑ Walk distance. ↓ General pain	N/A
2002 Badria [24]	DB, PC, RCT	45	12		500	↑ Walk distance. ↓ General pain	↓ Oxidative stress markers

↑↓ Indicates an increase or decrease in the value of the respective variable, ⇄ Indicates that no change occurred in that respective variable. Abbreviations for Table 1: CGIC: Clinical Global impression of change. CRP: C-reactive protein levels. DB: Double-blind. ESR: Erythrocyte Sedimentation Rate: GI AE: Gastrointestinal adverse event. IL: Interleukin. KOOS: Knee injury and Osteoarthritis Outcome Score. LPFI: Lateral patellar facet impingement. MDA: Malondialdehyde. NSAID: Nonsteroidal anti-inflammatory drug. OBS: Observational study. PC: Placebo controlled. PhyGA: Physician’s global assessment. RCT: Randomized controlled trial. RFT: Renal function tests. ROM: Range of motion. ROS: Reactive oxygen species. SB: Single-blind. sCD40L: Soluble cluster of differentiation 40 ligand. sVCAM: Soluble vascular cell adhesion molecule 1. TUG: Timed up-and-go test. VAS: Visual analogue scale. WOMAC: Western Ontario and McMaster Universities Arthritis Index.